HBV Mutation Detail Information

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Mutation Information
Mutation Site D134S
Mutation Type Amino acid level
Gene/Protein/Region Type RT
Genotype/Subtype C
Viral Reference GQ872210
Country Japan
Literature Information
PubMed PMID 33462964
Disease Chronic hepatitis B
Published Year 2021
Journal Hepatology research : the official journal of the Japan Society of Hepatology
Title Virologic analysis of tenofovir resistance in a patient with chronic hepatitis B experiencing viral breakthrough during combination treatment with tenofovir disoproxil fumarate and entecavir.
Author Suzuki F,Sezaki H,Hosaka T,Suzuki Y,Fujiyama S,Kawamura Y,Akuta N,Kobayashi M,Saitoh S,Arase Y,Ikeda K,Kobayashi M,Mineta R,Suzuki Y,Kumada H
Evidence Four mutations (rtS106C, rtD134N/S[N/S], rtM204V, and rtL269I) plus ETV resistance (rtL180M and rtS202G) existed when she developed viral breakthrough during ETV and TDF combination therapy in April 2013.

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation