Mutation Information
Mutation Site
|
D134S |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
RT |
Genotype/Subtype
|
C |
Viral Reference
|
GQ872210
|
Country
|
Japan |
Literature Information
PubMed PMID
|
33462964
|
Disease
|
Chronic hepatitis B
|
Published Year
|
2021 |
Journal
|
Hepatology research : the official journal of the Japan Society of Hepatology |
Title
|
Virologic analysis of tenofovir resistance in a patient with chronic hepatitis B experiencing viral breakthrough during combination treatment with tenofovir disoproxil fumarate and entecavir. |
Author
|
Suzuki F,Sezaki H,Hosaka T,Suzuki Y,Fujiyama S,Kawamura Y,Akuta N,Kobayashi M,Saitoh S,Arase Y,Ikeda K,Kobayashi M,Mineta R,Suzuki Y,Kumada H |
Evidence
|
Four mutations (rtS106C, rtD134N/S[N/S], rtM204V, and rtL269I) plus ETV resistance (rtL180M and rtS202G) existed when she developed viral breakthrough during ETV and TDF combination therapy in April 2013.
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