|
Mutation Information
|
Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204V+rt.L180M |
|
Genotype/Subtype
|
A;F |
|
Relevant Drug
|
lamivudine (LAM) |
|
Country
|
Brazil |
Literature Information
|
PubMed PMID
|
18036224
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2007 |
|
Journal
|
BMC microbiology |
|
Title
|
Hepatitis B virus genotypes circulating in Brazil: molecular characterization of genotype F isolates. |
|
Author
|
Mello FC,Souto FJ,Nabuco LC,Villela-Nogueira CA,Coelho HS,Franz HC,Saraiva JC,Virgolino HA,Motta-Castro AR,Melo MM,Martins RM,Gomes SA |
|
Evidence
|
One (209-CW) displayed the double rtL180M-rtM204V lamivudine-resistance mutation and the other (043-N) showed an additional rtV173L mutation, which is also associated with lamivudine resistance (Table 2).
|
|
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HBV Mutation Detail Information