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Mutation Information
|
Mutation Site
|
M204V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.L180M+rt.M204V |
|
Relevant Drug
|
lamivudine (LAM) |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
21933446
|
|
Disease
|
Chronic hepatitis B;
Hepatocellular carcinoma
|
|
Published Year
|
2011 |
|
Journal
|
BMC cancer |
|
Title
|
Emergence of the rtA181T/sW172* mutant increased the risk of hepatoma occurrence in patients with lamivudine-resistant chronic hepatitis B. |
|
Author
|
Yeh CT,Chen T,Hsu CW,Chen YC,Lai MW,Liang KH,Chen TC |
|
Evidence
|
Virological factors including HBV-DNA level, genotype, precore G1896A, BCP A1762T/G1764A, rtM204I/V, rtA181T and pre-S internal deletion mutations as well as clinical variables including subsequent use of rescue drugs were submitted for outcome analysis.
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HBV Mutation Detail Information