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Mutation Information
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Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204V+rt.L180M+rt.L229V;rt.M204V+rt.L180M+rt.L229M |
|
Amino acid_Mutation
|
T/C667A |
|
Relevant Drug
|
lamivudine (LAM) |
|
Country
|
china |
Literature Information
|
PubMed PMID
|
33124952
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2020 |
|
Journal
|
Emerging microbes & infections |
|
Title
|
Mutational characterization of HBV reverse transcriptase gene and the genotype-phenotype correlation of antiviral resistance among Chinese chronic hepatitis B patients. |
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Author
|
Fu Y,Wu S,Hu Y,Chen T,Zeng Y,Liu C,Ou Q |
|
Evidence
|
Putative resistance mutations were observed at 8 AA sites among the panel of treatment-naive patients; they were rtV191I, rtS213T, rtV214A, rtE218D, rtL229V, rtI233V, rtN238S, rtS/C256G. The classical NA-r mutations rtL180M (ntT/C667A) and rtM204V/I (ntA739G or ntG741T/A), were treatment-specific and were preferentially present in post-treatment patients.
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HBV Mutation Detail Information