|
Mutation Information
|
Mutation Site
|
M204I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
12747252
|
|
Disease
|
HBV infection
|
|
Published Year
|
2003 |
|
Journal
|
Rinsho byori. The Japanese journal of clinical pathology |
|
Title
|
Development of peptide nucleic acid mediated polymerase chain reaction clamping (PMPC)--direct sequencing method for detecting lamivudine-resistant hepatitis B virus (HBV) variants with high sensitivity and specificity. |
|
Author
|
Ogata N,Ichida T,Aoyagi Y,Kitajima I |
|
Evidence
|
Educed sensitivity of HBV to lamivudine, which causes a viral breakthrough during treatment, is attributed to mutations within the tyrosine-methionine-aspartate(YMDD) locus in the reverse transcriptase(rt) domain of HBV polymerase, mainly a methionine(rtM204) substitution.
|
|
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HBV Mutation Detail Information