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Mutation Information
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Mutation Site
|
N236T |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.N238T+rt.N236T;rt.N236T+rt.A181V;rt.N236T+rt.A181T |
|
Relevant Drug
|
lamivudine (LAM);adefovir (ADV) |
Literature Information
|
PubMed PMID
|
18331765
|
|
Disease
|
HBV infection
|
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Published Year
|
2008 |
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Journal
|
Journal of hepatology |
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Title
|
Impact of hepatitis B virus rtA181V/T mutants on hepatitis B treatment failure. |
|
Author
|
Villet S,Pichoud C,Billioud G,Barraud L,Durantel S,Trépo C,Zoulim F |
|
Evidence
|
RESULTS: Clonal analysis revealed the co-localization on the same HBV genome of rtA181T/V with rtN236T, but not with rtM204V/I mutations following lamivudine, adefovir or lamivudine+adefovir breakthrough.
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HBV Mutation Detail Information