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Mutation Information
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Mutation Site
|
M204V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204V+rt.L180M;rt.M204V+rt.L180M+rt.V173L |
|
Relevant Drug
|
adefovir (ADV);lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
22314422
|
|
Published Year
|
2012 |
|
Journal
|
Journal of hepatology |
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Title
|
Decreased infectivity of nucleoside analogs-resistant hepatitis B virus mutants. |
|
Author
|
Billioud G,Pichoud C,Parent R,Zoulim F |
|
Evidence
|
METHODS: HBV-resistant mutants (rtL180M+M204V, rtV173L+L180M+M204V, rtM204I, rtL180M+M204I, rtN236T, rtA181V, rtA181V+rtN236T, rtA181T+N236T, and rtA181T) were produced in HepG2 cells permanently expressing the respective viral genomes.
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HBV Mutation Detail Information