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Mutation Information
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Mutation Site
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T128I |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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RT |
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Relevant Drug
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lamivudine (LAM) |
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Country
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Iran |
Literature Information
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PubMed PMID
|
23596461
|
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Disease
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Hepatocellular carcinoma;
Chronic hepatitis B;
Liver cirrhosis;
Acute hepatitis B;
Fulminant hepatitis B
|
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Published Year
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2013 |
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Journal
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Hepatitis monthly |
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Title
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Drug-related mutational patterns in hepatitis B virus (HBV) reverse transcriptase proteins from Iranian treatment-naïve chronic HBV patients. |
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Author
|
Mahabadi M,Norouzi M,Alavian SM,Samimirad K,Azad TM,Saberfar E,Mahmoodi M,Ramezani F,Karimzadeh H,Malekzadeh R,Montazeri G,Nejatizadeh A,Ziaee M,Abedi F,Ataei B,Yaran M,Sayad B,Hossein Somi M,Sarizadeh G,Sanei-Moghaddam I,Mansour-Ghanaei F,Rafatpanah H,Pourhosseingholi MA,Keyvani H,Kalantari E,Saberifiroozi M,Ali Judaki M,Ghamari S,Daram M,Fazeli Z,Goodarzi Z,Khedive A,Moradi A,Jazayeri SM |
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Evidence
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Common and frequent lamivudine-related amino acid substitutions were found in this study including N53K 3.68% (12/325), L80V/I 3.07% (each 5/325), L82M1.22% (4/325) L91I 7.06% (23/325), T128I 1,53% (5/325), L180M3.37% (11/325), and M204I2.76%(9/325) M204V 1.23% (4/325) see Figure 1.
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HBV Mutation Detail Information