HBV Mutation Detail Information

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Mutation Information

Mutation Site	M204V
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Combined Mutation	rt.S202G+rt.M204V+rt.L180M
Relevant Drug	lamivudine (LAM);entecavir (ETV)

Literature Information

PubMed PMID	23237841
Published Year	2013
Journal	Bioorganic & medicinal chemistry letters
Title	2'-Fluoro-6'-methylene-carbocyclic adenosine phosphoramidate (FMCAP) prodrug: in vitro anti-HBV activity against the lamivudine-entecavir resistant triple mutant and its mechanism of action.
Author	Rawal RK,Singh US,Chavre SN,Wang J,Sugiyama M,Hung W,Govindarajan R,Korba B,Tanaka Y,Chu CK
Evidence	Novel 2'-fluoro-6'-methylene-carbocyclic adenosine (FMCA) monophosphate prodrug (FMCAP) was synthesized and evaluated for its in vitro anti-HBV potency against a lamivudine-entecavir resistant clone (L180M+M204V+S202G).

Contents
Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation