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Mutation Information
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Mutation Site
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A181V |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
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RT |
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Relevant Drug
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lamivudine (LAM);adefovir (ADV);tenofovir (TDF) |
Literature Information
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PubMed PMID
|
22505793
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Published Year
|
2011 |
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Journal
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International journal of current chemistry |
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Title
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Hepatitis B Virus genotypic differences map structurally close to NRTI resistance hot spots. |
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Author
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Michailidis E,Singh K,Kirby KA,Hachiya A,Yoo W,Hong SP,Kim SO,Folk WR,Sarafianos SG |
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Evidence
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Specifically, the L180M mutation causes resistance to LVD, ETV and TDF, the A181V/T mutation causes resistance to LVD, ADV and TDF, and T184G/L/S mutation causes resistance to LVD and ETV.
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HBV Mutation Detail Information