Mutation Information
Mutation Site
|
N236T |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
RT |
Relevant Drug
|
adefovir (ADV);lamivudine (LAM) |
Country
|
China |
Literature Information
PubMed PMID
|
21513743
|
Disease
|
HBV infection
|
Published Year
|
2011 |
Journal
|
Journal of virological methods |
Title
|
Detection of lamivudine- or adefovir-resistant hepatitis B virus mutations by a liquid array. |
Author
|
Liu H,Mao R,Fan L,Xia J,Li Y,Yin Y,Li X,Zhao X,Guo H,Zhu H,Zhang Y,Kang Y,Zhang J |
Evidence
|
A novel polymerase chain reaction (PCR)-Luminex assay was developed for rapid, accurate, and high-throughput detection of the most important hepatitis B virus (HBV) variants, including those with reverse transcriptase (RT) domain L180M, M204I/V, A181T/V/S, I233V and N236T mutations associated with resistance to lamivudine (LAM) or adefovir (ADV).
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