HBV Mutation Detail Information

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Mutation Information

Mutation Site	L180M
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Combined Mutation	rt.M204V+rt.L180M;rt.N236T+rt.M204V+rt.L180M
Genotype/Subtype	D
Relevant Drug	adefovir (ADV);lamivudine (LAM);emtricitabine (FTC);clevudine (L-FMAU);Elvucitabine (β‐L‐FD4C)

Literature Information

PubMed PMID	15915463
Published Year	2005
Journal	Hepatology (Baltimore, Md.)
Title	Susceptibility to antivirals of a human HBV strain with mutations conferring resistance to both lamivudine and adefovir.
Author	Brunelle MN,Jacquard AC,Pichoud C,Durantel D,Carrouée-Durantel S,Villeneuve JP,Trépo C,Zoulim F
Evidence	Considering the use of de novo or add-on 3TC+ADV bitherapy, we investigated the possibility of the emergence of an HBV strain harboring polymerase mutations conferring resistance to both 3TC (rtL180M+M204V) and ADV (rtN236T).

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation