HBV Mutation Detail Information

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Mutation Information

Mutation Site	N236T
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Combined Mutation	rt.N236T+rt.A181T
Relevant Drug	adefovir (ADV)

Literature Information

PubMed PMID	18571815
Disease	Chronic hepatitis B
Published Year	2008
Journal	Hepatology (Baltimore, Md.)
Title	Defective hepatitis B virus DNA is not associated with disease status but is reduced by polymerase mutations associated with drug resistance.
Author	Preiss S,Littlejohn M,Angus P,Thompson A,Desmond P,Lewin SR,Sasadeusz J,Matthews G,Dore GJ,Shaw T,Sozzi V,Yuen L,Lau G,Ayres A,Thio C,Avihingsanon A,Ruxrungtham K,Locarnini S,Revill PA
Evidence	The adefovir resistance (ADVr) mutant rtN236T and the double mutant rtA181T+rtN236T also had significantly lower % dDNA relative to wild-type isolated from the cell supernatant, although there was no significant difference in intracellular core-associated % dDNA.

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Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation