HBV Mutation Detail Information

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Mutation Information

Mutation Site	M204V
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Combined Mutation	rtM204V + rtV173L
Genotype/Subtype	A;D
Viral Reference	JN182318.1; GU456636.1
Relevant Drug	lamivudine (LAM);telbivudine (LDT);entecavir (ETV)

Literature Information

PubMed PMID	29859062
Disease	Chronic hepatitis B
Published Year	2018
Journal	BMC infectious diseases
Title	Immune-escape mutations and stop-codons in HBsAg develop in a large proportion of patients with chronic HBV infection exposed to anti-HBV drugs in Europe.
Author	Colagrossi L,Hermans LE,Salpini R,Di Carlo D,Pas SD,Alvarez M,Ben-Ari Z,Boland G,Bruzzone B,Coppola N,Seguin-Devaux C,Dyda T,Garcia F,Kaiser R,Köse S,Krarup H,Lazarevic I,Lunar MM,Maylin S,Micheli V,Mor O,Paraschiv S,Paraskevis D,Poljak M,Puchhammer-Stöckl E,Simon F,Stanojevic M,Stene-Johansen K,Tihic N,Trimoulet P,Verheyen J,Vince A,Lepej SZ,Weis N,Yalcinkaya T,Boucher CAB,Wensing AMJ,Perno CF,Svicher V,HEPVIR working group of the European Society for translational antiviral research (ESAR).
Evidence	Strong correlation was observed between sP120T and rtM204I/V (P < 0.001), and their co-presence determined an increased HBV-DNA.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation