|
Mutation Information
|
Mutation Site
|
V278I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Genotype/Subtype
|
A |
|
Viral Reference
|
X02763.1
|
|
Relevant Drug
|
tenofovir (TDF);lamivudine (LAM) |
|
Country
|
South Africa |
Literature Information
|
PubMed PMID
|
31248149
|
|
Clinical information
|
Yes
|
|
Disease
|
HBV infection
|
|
Published Year
|
2019 |
|
Journal
|
Viruses |
|
Title
|
Frequency of Hepatitis B Virus Resistance Mutations in Women Using Tenofovir Gel as Pre-Exposure Prophylaxis. |
|
Author
|
Baxter C,Ngcapu S,Blackard JT,Powell EA,Penton PK,Abdool Karim SS |
|
Evidence
|
Although the frequency of amino acid substitutions were not significantly different, a total of 16 amino acid substitutions in the polymerase domain occurred only in tenofovir-experienced isolates compared to tenofovir-naive isolates, including S117Y, S117C, I121N, T128I, M129L, R138K, R138E, L140P, V142A, I163V, L217R, N238H, R242K, K270R, V278I, and R280S. Positions R110G, Y126H, T128S, W153R, L220I, T225I, P237H, T259S and H271C were highly polymorphic in tenofovir-naive compared to tenofovir-experienced isolates. No mutations known to cause tenofovir resistance (L180M, A181I/V, A194T, M204V/I, V214A, Q215S, N236T) or lamuvudine (3TC) resistance (L80V/I, I169T, V173L, L180M, A181T, T184S, M204V/I/S, Q215S) were observed. Absence of these mutations was also confirmed using the INNO-LiPA HBV DR v3 commercial kit (Innogenetics, N.V., Gent, Belgium)
|
|
|
HBV Mutation Detail Information