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Mutation Information
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Mutation Site
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M204V |
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Mutation Type
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Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Combined Mutation
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rt.L180M+rt.M204V;rt.L180M+rt.V173L+rt.M204V;rt.L180M+rt.L80V+rt.L80I+rt.M204V;rt.L180M+rt.V173L+rt.L80V+rt.L80I+rt.M204V |
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Genotype/Subtype
|
B;C |
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Relevant Drug
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lamivudine (LAM);telbivudine (LDT);adefovir (ADV) |
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Country
|
China |
Literature Information
|
PubMed PMID
|
24160943
|
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Disease
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Chronic hepatitis B
|
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Published Year
|
2013 |
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Journal
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Virology journal |
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Title
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Profile of hepatitis B virus resistance mutations against nucleoside/nucleotide analogue treatment in Chinese patients with chronic hepatitis B. |
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Author
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Lei J,Wang Y,Wang LL,Zhang SJ,Chen W,Bai ZG,Xu LY |
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Evidence
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Among LAM/LdT based therapies, HBV rtM204I was significantly associated with HBV rtL80I/V mutations [rtM204I+rtL80I/V (50.0%, 32/64) vs. rtM204V+rtL80I/V (27.3%,9/33), P=0.032]; while the HBV rtM204V mutations was significantly associated with HBV rtL180M mutations [rtM204V+rtL180M (100%, 33/33) vs. rtM204I+rtL180M (60.9%, 39/64), P<0.001].
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HBV Mutation Detail Information