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Mutation Information
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Mutation Site
|
M204I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Genotype/Subtype
|
B;C |
|
Relevant Drug
|
lamivudine (LAM) |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
30906435
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2019 |
|
Journal
|
Experimental and therapeutic medicine |
|
Title
|
Viral quasispecies of hepatitis B virus in patients with YMDD mutation and lamivudine resistance may not predict the efficacy of lamivudine/adefovir rescue therapy. |
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Author
|
Wang C,Yu S,Zhang Y,Zhang M,Lv L,Huang C,Li X,Li J,Zhang Z |
|
Evidence
|
In the present study, 16 CHB patients with the rtM204I/V mutation in the tyrosine-methionine-aspartate-aspartate motif of the C domain of the polymerase gene who switched to LAM/ADV treatment due to LAM resistance were assessed.
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HBV Mutation Detail Information