|
Mutation Information
|
Mutation Site
|
D134E |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Genotype/Subtype
|
C |
|
Viral Reference
|
GQ872210
|
|
Relevant Drug
|
Tenofovir (TDF) |
|
Country
|
Korea |
Literature Information
|
PubMed PMID
|
30794889
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2019 |
|
Journal
|
Journal of hepatology |
|
Title
|
Identification of a quadruple mutation that confers tenofovir resistance in chronic hepatitis B patients. |
|
Author
|
Park ES,Lee AR,Kim DH,Lee JH,Yoo JJ,Ahn SH,Sim H,Park S,Kang HS,Won J,Ha YN,Shin GC,Kwon SY,Park YK,Choi BS,Lee YB,Jeong N,An Y,Ju YS,Yu SJ,Chae HB,Yu KS,Kim YJ,Yoon JH,Zoulim F,Kim KH |
|
Evidence
|
RESULTS: Five mutations (rtS106C [C], rtH126Y [Y], rtD134E [E], rtM204I/V, and rtL269I [I]) were commonly found in viral isolates from 2 patients.
|
|
|
HBV Mutation Detail Information