Mutation Information
Mutation Site
|
L180M |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
RT |
Combined Mutation
|
s.W196F+s.W199C+rt.V173L+rt.L180M+rt.M204V;s.W196L+rt.L180M |
Relevant Drug
|
lamivudine (LAM) |
Country
|
China |
Literature Information
PubMed PMID
|
16830379
|
Disease
|
Chronic hepatitis B
|
Published Year
|
2006 |
Journal
|
World journal of gastroenterology |
Title
|
Mutations in surface and polymerase gene of chronic hepatitis B patients with coexisting HBsAg and anti-HBs. |
Author
|
Lu HY,Zeng Z,Xu XY,Zhang NL,Yu M,Gong WB |
Evidence
|
Because the S gene overlaps with the major calatytic domain of the polymerase gene, the mutations near the YMDD motif of the polymerase gene were studied. Eight mutations within amino acid residues 518-569 of the polymerase gene were observed at 4 positions (V173L, L180M, M204I/V, S223A) in 5 patients.
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