HBV Mutation Detail Information

> A181V Search Result

Mutation Information

Mutation Site	A181V
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Relevant Drug	adefovir (ADV);lamivudine (LAM);tenofovir (TDF)

Literature Information

PubMed PMID	17302381
Disease	Chronic hepatitis B
Published Year	2006
Journal	Antiviral therapy
Title	Unusual selection of rtA181V HBV mutants cross-resistant to adefovir following prolonged lamivudine monotherapy: report of two cases.
Author	Gerolami R,Bourliere M,Colson P,Halfon P,Borentain P,Henry M,Botta D,Thibault V,Khiri H,Tamalet C
Evidence	The A181V mutation within the reverse transcriptase (RT) of HBV has been shown to be associated with HBV resistance to adefovir dipivoxil (ADV), and its level of sensitivity to other nucleos(t)ide analogues is an important issue.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation