|
Mutation Information
|
Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204I+rt.L180M |
|
Relevant Drug
|
entecavir (ETV) |
Literature Information
|
PubMed PMID
|
26349829
|
|
Published Year
|
2015 |
|
Journal
|
Antimicrobial agents and chemotherapy |
|
Title
|
A novel pyridazinone derivative inhibits hepatitis B virus replication by inducing genome-free capsid formation. |
|
Author
|
Wang YJ,Lu D,Xu YB,Xing WQ,Tong XK,Wang GF,Feng CL,He PL,Yang L,Tang W,Hu YH,Zuo JP |
|
Evidence
|
Both the 3TC/ETV dually resistant L180M/M204I mutant and the adefovir (ADV)-resistant A181T/N236T mutant were as susceptible to 3711 as wild-type HBV.
|
|
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HBV Mutation Detail Information