|
Mutation Information
|
Mutation Site
|
M250L |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
entecavir (ETV) |
Literature Information
|
PubMed PMID
|
18435459
|
|
Disease
|
HBV infection
|
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Published Year
|
2008 |
|
Journal
|
Hepatology (Baltimore, Md.) |
|
Title
|
Comprehensive evaluation of hepatitis B virus reverse transcriptase substitutions associated with entecavir resistance. |
|
Author
|
Baldick CJ,Tenney DJ,Mazzucco CE,Eggers BJ,Rose RE,Pokornowski KA,Yu CF,Colonno RJ |
|
Evidence
|
Substitutions rtM250L and I have also been found in patients with the rtM204I LVDr substitution, but the levels of resistance for these clones is relatively low (average ETV EC50 of 121 and 48 nM, respectively).
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HBV Mutation Detail Information