|
Mutation Information
|
Mutation Site
|
M204V |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204V+rt.L180M |
|
Relevant Drug
|
lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
12760870
|
|
Published Year
|
2003 |
|
Journal
|
Antimicrobial agents and chemotherapy |
|
Title
|
Generation of stable cell lines expressing Lamivudine-resistant hepatitis B virus for antiviral-compound screening. |
|
Author
|
Walters KA,Tipples GA,Allen MI,Condreay LD,Addison WR,Tyrrell L |
|
Evidence
|
Replication-competent HBV constructs containing the reverse transcriptase domain L180M/M204V and M204I (rtL180M/M204V and rtM204I) mutations associated with lamivudine resistance were used to produce stable cell line that express the resistant virus.
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HBV Mutation Detail Information