|
Mutation Information
|
Mutation Site
|
N236T |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.A181T+rt.N236T |
|
Genotype/Subtype
|
C |
|
Relevant Drug
|
adefovir (ADV) |
|
Country
|
Korea |
Literature Information
|
PubMed PMID
|
21777282
|
|
Disease
|
HBV infection
|
|
Published Year
|
2012 |
|
Journal
|
Journal of gastroenterology and hepatology |
|
Title
|
rtL180M mutation of hepatitis B virus is closely associated with frequent virological resistance to adefovir dipivoxil therapy. |
|
Author
|
Lee YS,Chung YH,Kim JA,Jin YJ,Park WH,Kim SE,Lee D,Shim JH,Kim KM,Lim YS,Lee HC,Lee YS,Suh DJ |
|
Evidence
|
ADV‐resistant mutations were identified in four (20%) of the 20 patients at the time of VB, specifically, two with rtN236T, one with rtA181T, and one with rtN236T + rtA181T.
|
|
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HBV Mutation Detail Information