|
Mutation Information
|
Mutation Site
|
M204I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
lamivudine (LAM) |
|
Country
|
Finland |
Literature Information
|
PubMed PMID
|
21462295
|
|
Disease
|
HBV infection
|
|
Published Year
|
2011 |
|
Journal
|
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society |
|
Title
|
Hepatitis B virus quasispecies in hepatic and extrahepatic viral reservoirs in liver transplant recipients on prophylactic therapy. |
|
Author
|
Coffin CS,Mulrooney-Cousins PM,van Marle G,Roberts JP,Michalak TI,Terrault NA |
|
Evidence
|
An HBV lamivudine-resistant variant with an M204I mutation was identified in liver (70% and 18% of the clones) and plasma samples (100% of the clones), but a WT sequence was found in 70% and 100% of the PBMC clones.
|
|
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HBV Mutation Detail Information