HBV Mutation Detail Information

> L180M Search Result

Mutation Information

Mutation Site	L180M
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Genotype/Subtype	D
Relevant Drug	lamivudine (LAM);entecavir (ETV)

Literature Information

PubMed PMID	20169198
Published Year	2010
Journal	PloS one
Title	Mechanistic characterization and molecular modeling of hepatitis B virus polymerase resistance to entecavir.
Author	Walsh AW,Langley DR,Colonno RJ,Tenney DJ
Evidence	Changes in the HBV polymerase reverse-transcriptase (RT) domain involve lamivudine-resistance (LVDr) substitutions in the conserved YMDD motif (M204V/I +- L180M), plus an additional ETV-specific change at residues T184, S202 or M251.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation