HBV Mutation Detail Information

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Mutation Information
Mutation Site M250I
Mutation Type Amino acid level
Gene/Protein/Region Type RT
Relevant Drug entecavir (ETV);lamivudine (LAM)
Literature Information
PubMed PMID 17178796
Disease Chronic hepatitis B
Published Year 2007
Journal Antimicrobial agents and chemotherapy
Title Two-year assessment of entecavir resistance in Lamivudine-refractory hepatitis B virus patients reveals different clinical outcomes depending on the resistance substitutions present.
Author Tenney DJ,Rose RE,Baldick CJ,Levine SM,Pokornowski KA,Walsh AW,Fang J,Yu CF,Zhang S,Mazzucco CE,Eggers B,Hsu M,Plym MJ,Poundstone P,Yang J,Colonno RJ
Evidence The T184, S202, or M250 substitution was found in LVDr HBV at baseline in 6% of patients and emerged in isolates from another 11/187 (6%) and 12/151 (8%) ETV-treated patients by Weeks 48 and 96, respectively

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation