|
Mutation Information
|
Mutation Site
|
H124N |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Genotype/Subtype
|
D |
|
Relevant Drug
|
lamivudine (LAM);tenofovir (TDF) |
|
Country
|
India |
Literature Information
|
PubMed PMID
|
28303969
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2017 |
|
Journal
|
Scientific reports |
|
Title
|
HBV quasispecies composition in Lamivudine-failed chronic hepatitis B patients and its influence on virological response to Tenofovir-based rescue therapy. |
|
Author
|
Banerjee P,Chakraborty A,Mondal RK,Khatun M,Datta S,Das K,Pandit P,Mukherjee S,Banerjee S,Ghosh S,Chakrabarti S,Chowdhury A,Datta S |
|
Evidence
|
Significantly high frequencies of 6 S-substitutions and one novel RT-substitution, rtH124N with 6.5-fold-reduced susceptibility to TDF in vitro, were noted at baseline in TDF non-responders than responders.
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HBV Mutation Detail Information