HBV Mutation Detail Information

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Mutation Information

Mutation Site	A181T
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Combined Mutation	rt.N236T+rt.A181T;rt.M204I+rt.A181T
Relevant Drug	adefovir (ADV);lamivudine (LAM)
Country	Japan

Literature Information

PubMed PMID	18433925
Disease	Chronic hepatitis B
Published Year	2008
Journal	Journal of hepatology
Title	Low risk of adefovir resistance in lamivudine-resistant chronic hepatitis B patients treated with adefovir plus lamivudine combination therapy: two-year follow-up.
Author	Yatsuji H,Suzuki F,Sezaki H,Akuta N,Suzuki Y,Kawamura Y,Hosaka T,Kobayashi M,Saitoh S,Arase Y,Ikeda K,Watahiki S,Iwasaki S,Kobayashi M,Kumada H
Evidence	At the beginning of ADV therapy, substitutions at rtA181 (rtA181T and rtA181S) were identified in 3 patients (2.3%).

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation