HBV Mutation Detail Information

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Mutation Information

Mutation Site	L180M
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Combined Mutation	rt.M204V+rt.L180M
Relevant Drug	lamivudine (LAM);adefovir (ADV);adefovir dipivoxil (ADV)
Country	France

Literature Information

PubMed PMID	15664258
Disease	Chronic hepatitis B
Published Year	2005
Journal	Journal of hepatology
Title	Sustained HBs seroconversion during lamivudine and adefovir dipivoxil combination therapy for lamivudine failure.
Author	Maynard M,Parvaz P,Durantel S,Chevallier M,Chevallier P,Lot M,Trepo C,Zoulim F
Evidence	Lamivudine resistance was associated with the selection of a L180M+M204V polymerase mutant.

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Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation