|
Mutation Information
|
Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
11230757
|
|
Published Year
|
2001 |
|
Journal
|
Hepatology (Baltimore, Md.) |
|
Title
|
Nomenclature for antiviral-resistant human hepatitis B virus mutations in the polymerase region. |
|
Author
|
Stuyver LJ,Locarnini SA,Lok A,Richman DD,Carman WF,Dienstag JL,Schinazi RF |
|
Evidence
|
In this proposal, the HBV rt domain starts with the highly conserved EDWGPCDEHG motif, contains 344 amino acids, and the lamivudine-related resistance mutations are found at amino acid rtL180M (previously amino acid 528, 526, 515, or 525) and rtM204V/I (previously 552, 550, 539, or 549).
|
|
|
HBV Mutation Detail Information