HBV Mutation Detail Information

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Mutation Information
Mutation Site L180M
Mutation Type Amino acid level
Gene/Protein/Region Type RT
Combined Mutation rt.M204I+rt.L180M
Relevant Drug lamivudine (LAM)
Country China
Literature Information
PubMed PMID 25028473
Disease Chronic hepatitis B
Published Year 2014
Journal The Journal of general virology
Title Impact of the rtI187V polymerase substitution of hepatitis B virus on viral replication and antiviral drug susceptibility.
Author Fan J,Wang Y,Xiong H,Guo X,Cheng YC
Evidence Replication-competent HBV constructs containing rtI187V and combined with LAM-resistant (rtM204I, rtL180M/rtM204V) mutations were generated, and compared with WT, LAM-resistant single (rtM204I) or double (rtL180M/rtM204V) and ADV-resistant (rtN236T) clones.

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation