Mutation Information
Mutation Site
|
L180M |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
RT |
Combined Mutation
|
rt.M204I+rt.L180M |
Relevant Drug
|
lamivudine (LAM) |
Country
|
China |
Literature Information
PubMed PMID
|
25028473
|
Disease
|
Chronic hepatitis B
|
Published Year
|
2014 |
Journal
|
The Journal of general virology |
Title
|
Impact of the rtI187V polymerase substitution of hepatitis B virus on viral replication and antiviral drug susceptibility. |
Author
|
Fan J,Wang Y,Xiong H,Guo X,Cheng YC |
Evidence
|
Replication-competent HBV constructs containing rtI187V and combined with LAM-resistant (rtM204I, rtL180M/rtM204V) mutations were generated, and compared with WT, LAM-resistant single (rtM204I) or double (rtL180M/rtM204V) and ADV-resistant (rtN236T) clones.
|
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