|
Mutation Information
|
Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.V173L+rt.M204V+rt.L180M |
|
Relevant Drug
|
lamivudine (LAM) |
|
Country
|
Germany |
Literature Information
|
PubMed PMID
|
16871563
|
|
Clinical information
|
Yes
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2006 |
|
Journal
|
Hepatology (Baltimore, Md.) |
|
Title
|
Tenofovir for patients with lamivudine-resistant hepatitis B virus (HBV) infection and high HBV DNA level during adefovir therapy. |
|
Author
|
van Bömmel F,Zöllner B,Sarrazin C,Spengler U,Hüppe D,Möller B,Feucht HH,Wiedenmann B,Berg T |
|
Evidence
|
Lamivudine-associated mutations (rtV173L, rtL180M, rtM204V/I) could be detected in 6 patients at baseline of TDF, but this obviously did not influence the response.
|
|
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HBV Mutation Detail Information