HBV Mutation Detail Information

> H133L Search Result

Mutation Information

Mutation Site	H133L
Mutation Type	Amino acid level
Gene/Protein/Region Type	RT
Relevant Drug	adefovir (ADV)

Literature Information

PubMed PMID	12829991
Disease	Chronic hepatitis B
Published Year	2003
Journal	Hepatology (Baltimore, Md.)
Title	Week 48 resistance surveillance in two phase 3 clinical studies of adefovir dipivoxil for chronic hepatitis B.
Author	Westland CE,Yang H,Delaney WE 4th,Gibbs CS,Miller MD,Wulfsohn M,Fry J,Brosgart CL,Xiong S,437 and 438 Study Teams.
Evidence	Four substitutions (rtS119A, rtH133L, rtV214A, and rtH234Q) developed once each at conserved sites in HBV polymerase in 4 ADV-treated patients.

Contents
Description

Mutation Information Note

Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)

Literature Information Note

Evidence: sentence contains this mutation information in the citation