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Mutation Information
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Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.N238H+rt.I224V+rt.M204V+rt.L180M |
|
Genotype/Subtype
|
B;C |
|
Relevant Drug
|
lamivudine (LAM);adefovir dipivoxil (ADV) |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
31147594
|
|
Disease
|
HBV infection
|
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Published Year
|
2019 |
|
Journal
|
Scientific reports |
|
Title
|
Potential resistant mutations within HBV reverse transcriptase sequences in nucleos(t)ide analogues-experienced patients with hepatitis B virus infection. |
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Author
|
Zhang X,Chen X,Wei M,Zhang C,Xu T,Liu L,Xu Z |
|
Evidence
|
In case three, multiple mutation patterns were observed from L180M + M204V + I224V + N238H to L180M + M204V + T184S + I224V + N238H under LAM and ADV combined therapy, which developed resistance to ETV.
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HBV Mutation Detail Information