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Mutation Information
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Mutation Site
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L180M |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Combined Mutation
|
rt.N236T+rt.M204V+rt.S202G+rt.A181V+rt.L180M |
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Genotype/Subtype
|
C |
|
Relevant Drug
|
lamivudine (LAM);adefovir (ADV);telbivudine (LDT);entecavir (ETV) |
|
Country
|
China |
Literature Information
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PubMed PMID
|
21392168
|
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Disease
|
Chronic hepatitis B;
Liver cirrhosis
|
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Published Year
|
2011 |
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Journal
|
Journal of viral hepatitis |
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Title
|
Genotypic resistance profile of hepatitis B virus (HBV) in a large cohort of nucleos(t)ide analogue-experienced Chinese patients with chronic HBV infection. |
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Author
|
Liu Y,Wang C,Zhong Y,Li X,Dai J,Ren X,Xu Z,Li L,Yao Z,Ji D,Wang L,Zhang L,Wong VW,Zoulim F,Xu D |
|
Evidence
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Multidrug-resistant HBV strains were identified in eight patients, including two novel strains with mutational patterns rtL180M + A181V + S202G + M204V + N236T and rtL180M + S202G + M204V + N238T.
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HBV Mutation Detail Information