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Mutation Information
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Mutation Site
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A194T |
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Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Viral Reference
|
U95551
|
Literature Information
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PubMed PMID
|
23261845
|
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Published Year
|
2013 |
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Journal
|
Antiviral research |
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Title
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The amino acid substitutions rtP177G and rtF249A in the reverse transcriptase domain of hepatitis B virus polymerase reduce the susceptibility to tenofovir. |
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Author
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Qin B,Budeus B,Cao L,Wu C,Wang Y,Zhang X,Rayner S,Hoffmann D,Lu M,Chen X |
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Evidence
|
For pHBV1.3-rtF88L, rtP177G, rtA194T, -rtM204I and -rtM204V, single-stranded (SS) DNA bands were synthesized, whereas the relaxed circular (RC) DNA bands were relatively weak or invisible.
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HBV Mutation Detail Information