HBV Mutation Detail Information

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Mutation Information
Mutation Site A181T
Mutation Type Amino acid level
Gene/Protein/Region Type RT
Combined Mutation rt.N236T+rt.A181T
Relevant Drug adefovir (ADV)
Literature Information
PubMed PMID 18571815
Disease Chronic hepatitis B
Published Year 2008
Journal Hepatology (Baltimore, Md.)
Title Defective hepatitis B virus DNA is not associated with disease status but is reduced by polymerase mutations associated with drug resistance.
Author Preiss S,Littlejohn M,Angus P,Thompson A,Desmond P,Lewin SR,Sasadeusz J,Matthews G,Dore GJ,Shaw T,Sozzi V,Yuen L,Lau G,Ayres A,Thio C,Avihingsanon A,Ruxrungtham K,Locarnini S,Revill PA
Evidence The adefovir resistance (ADVr) mutant rtN236T and the double mutant rtA181T+rtN236T also had significantly lower % dDNA relative to wild-type isolated from the cell supernatant, although there was no significant difference in intracellular core-associated % dDNA..

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation