Mutation Information
Mutation Site
|
A181T |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
RT |
Combined Mutation
|
rt.N236T+rt.A181T |
Relevant Drug
|
adefovir (ADV) |
Literature Information
PubMed PMID
|
18571815
|
Disease
|
Chronic hepatitis B
|
Published Year
|
2008 |
Journal
|
Hepatology (Baltimore, Md.) |
Title
|
Defective hepatitis B virus DNA is not associated with disease status but is reduced by polymerase mutations associated with drug resistance. |
Author
|
Preiss S,Littlejohn M,Angus P,Thompson A,Desmond P,Lewin SR,Sasadeusz J,Matthews G,Dore GJ,Shaw T,Sozzi V,Yuen L,Lau G,Ayres A,Thio C,Avihingsanon A,Ruxrungtham K,Locarnini S,Revill PA |
Evidence
|
The adefovir resistance (ADVr) mutant rtN236T and the double mutant rtA181T+rtN236T also had significantly lower % dDNA relative to wild-type isolated from the cell supernatant, although there was no significant difference in intracellular core-associated % dDNA..
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