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Mutation Information
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Mutation Site
|
A181G |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204V+rt.S202G+rt.A181G+rt.L180M |
|
Relevant Drug
|
lamivudine (LAM);entecavir (ETV) |
Literature Information
|
PubMed PMID
|
17239478
|
|
Disease
|
Chronic hepatitis B;
Liver cirrhosis
|
|
Published Year
|
2007 |
|
Journal
|
Journal of hepatology |
|
Title
|
Stepwise process for the development of entecavir resistance in a chronic hepatitis B virus infected patient. |
|
Author
|
Villet S,Ollivet A,Pichoud C,Barraud L,Villeneuve JP,Trépo C,Zoulim F |
|
Evidence
|
The addition of the rtA181G change to this triple mutant resulted in a 1.5-fold replication impairment, whereas the addition of rtI169L and rtV173L+P177S increased by 1.3- and 1.8-fold, respectively, the replication capacity of the same triple mutant.
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HBV Mutation Detail Information