HBV Mutation Detail Information

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Mutation Information
Mutation Site S135T
Mutation Type Amino acid level
Gene/Protein/Region Type RT
Combined Mutation p.M309K+rt.L229V+rt.K212Q+rt.A200V+rt.A181I+rt.S135T+rt.S85F+rt.S78T+rt.N53T;p.M309K+rt.L229F+rt.K212Q+rt.A200V+rt.A181I+rt.S135T+rt.S85F+rt.S78T+rt.N53T
Country Italy
Literature Information
PubMed PMID 23796863
Disease HBV infection
Published Year 2013
Journal The Journal of infection
Title Anti-HBV treatment induces novel reverse transcriptase mutations with reflective effect on HBV S antigen.
Author Cento V,Van Hemert F,Neumann-Fraune M,Mirabelli C,Di Maio VC,Salpini R,Bertoli A,Micheli V,Gubertini G,Romano S,Visca M,De Sanctis GM,Berkhout B,Marino N,Mazzotta F,Cappiello G,Spanò A,Sarrecchia C,Ceccherini-Silberstein F,Andreoni M,Angelico M,Verheyen J,Perno CF,Svicher V
Evidence RESULTS: Ten novel RT-mutations (rtN53T-rtS78T-rtS85F-rtS135T-rtA181I-rtA200V-rtK212Q-rtL229V/F-rtM309K) correlated with specific NUC-treatments and classical drug-resistance mutations on divergent evolutionary pathways.

Contents
Description
Mutation Information Note
  • Gene/Protein/Region Type: Virus Gene (e.g. LMP-1) or Virus Protein (e.g. Rep 68) or Virus Region (e.g. S, X)
Literature Information Note
  • Evidence: sentence contains this mutation information in the citation