Mutation Information
Mutation Site
|
I224V |
Mutation Type
|
Amino acid level |
Gene/Protein/Region Type
|
RT |
Combined Mutation
|
rt.N238H+rt.I224V+rt.F221Y;rt.N238A+rt.I224V;rt.N238T+rt.I224V;rt.N238H+rt.I224V+rt.M204V+rt.L180M;rt.N238H+rt.I224V+rt.T184S+rt.M204V |
Genotype/Subtype
|
C |
Relevant Drug
|
lamivudine (LAM);adefovir dipivoxil (ADV);entecavir (ETV) |
Country
|
China |
Literature Information
PubMed PMID
|
31147594
|
Disease
|
HBV infection
|
Published Year
|
2019 |
Journal
|
Scientific reports |
Title
|
Potential resistant mutations within HBV reverse transcriptase sequences in nucleos(t)ide analogues-experienced patients with hepatitis B virus infection. |
Author
|
Zhang X,Chen X,Wei M,Zhang C,Xu T,Liu L,Xu Z |
Evidence
|
Inthisstudy,non-classicalmutationswereobservedin29patientswhosufferingfromvirologicalbreakthroughandwithoutclassicalmutations(Table.4)at9sites(V191I,V207I/M,S213T,E218D,F221Y,I224V,L229V,N/H238andR242D).
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