|
Mutation Information
|
Mutation Site
|
N236T |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.N236T+rt.A181V |
|
Viral Reference
|
AM282986
|
|
Relevant Drug
|
adefovir (ADV);tenofovir (TDF) |
Literature Information
|
PubMed PMID
|
24814823
|
|
Published Year
|
2014 |
|
Journal
|
Current opinion in virology |
|
Title
|
Nucleoside/nucleotide analog inhibitors of hepatitis B virus polymerase: mechanism of action and resistance. |
|
Author
|
Menéndez-Arias L,Álvarez M,Pacheco B |
|
Evidence
|
Major mutational patterns conferring nucleoside/nucleotide analog resistance include the combinations rtL180M/rtM204(I/V) (for lamivudine, entecavir, telbivudine and clevudine) and rtA181V/rtN236T (for adefovir and tenofovir).
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HBV Mutation Detail Information