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Mutation Information
|
Mutation Site
|
M204I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
entecavir (ETV);lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
19231002
|
|
Clinical information
|
Yes
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2009 |
|
Journal
|
Journal of hepatology |
|
Title
|
Entecavir shows limited efficacy in HBeAg-positive hepatitis B patients with a partial virologic response to adefovir therapy. |
|
Author
|
Reijnders JG,Pas SD,Schutten M,de Man RA,Janssen HL |
|
Evidence
|
Two lamivudine-experienced patients demonstrated the rtM204I mutation; no other entecavir-resistant substitutions were detected (rtI169, rtT184, rtS202, and rtM250).
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HBV Mutation Detail Information