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Mutation Information
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Mutation Site
|
M204I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Viral Reference
|
AY090460;
AF160501;
X75657;
X02496;
AB033556;
D00330;
X02763 |
|
Country
|
Canada |
Literature Information
|
PubMed PMID
|
16757589
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2006 |
|
Journal
|
Journal of clinical microbiology |
|
Title
|
Detection of rtN236T and rtA181V/T mutations associated with resistance to adefovir dipivoxil in samples from patients with chronic hepatitis B virus infection by the INNO-LiPA HBV DR line probe assay (version 2). |
|
Author
|
Osiowy C,Villeneuve JP,Heathcote EJ,Giles E,Borlang J |
|
Evidence
|
LiPA analysis demonstrated that the rtN236T mutation and the rtM204V/I/S mutation (i.e., the major mutation associated with resistance to lamivudine) (5) appear to be mutually exclusive and develop sequentially after a switch from lamivudine therapy to ADV.
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HBV Mutation Detail Information