|
Mutation Information
|
Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204V+rt.L180M;rt.M204I+rt.L180M+rt.L80I;rt.M204V+rt.L180M+rt.L80V |
|
Genotype/Subtype
|
A |
|
Viral Reference
|
AY090459;
AB116092 |
|
Relevant Drug
|
lamivudine (LAM);entecavir (ETV) |
|
Country
|
Brazil |
Literature Information
|
PubMed PMID
|
28500726
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2017 |
|
Journal
|
Journal of medical virology |
|
Title
|
Mutations associated with drug resistance and prevalence of vaccine escape mutations in patients with chronic hepatitis B infection. |
|
Author
|
Dos Santos MIMA,Pacheco SR,Stocker A,Schinoni MI,Paraná R,Reis MG,Silva LK |
|
Evidence
|
Six patients (7%) exhibited resistance mutations to LAM, ETV, and TDF: two with patterns L180M + M204V and four with other different patterns: L80I + L180M + M204I; L80V + L180M + M204V; M204I; A194T.
|
|
|
HBV Mutation Detail Information