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Mutation Information
|
Mutation Site
|
M204I |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Relevant Drug
|
lamivudine (LAM) |
Literature Information
|
PubMed PMID
|
18537180
|
|
Disease
|
Chronic hepatitis B
|
|
Published Year
|
2008 |
|
Journal
|
Hepatology (Baltimore, Md.) |
|
Title
|
The antiviral drug selected hepatitis B virus rtA181T/sW172* mutant has a dominant negative secretion defect and alters the typical profile of viral rebound. |
|
Author
|
Warner N,Locarnini S |
|
Evidence
|
A review of the 1,440 patients in the SeqHepB database revealed that HBV encoding rtA181T/sW172* was detected by itself in 1%, and in association with M204I/V in 1% of LMV‐resistant cases (2% of total LMV‐resistant cases).
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HBV Mutation Detail Information