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Mutation Information
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Mutation Site
|
T184G |
|
Mutation Type
|
Amino acid level |
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Gene/Protein/Region Type
|
RT |
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Combined Mutation
|
rt.M204V+rt.S202I+rt.T184G+rt.L180M |
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Genotype/Subtype
|
D |
|
Relevant Drug
|
lamivudine (LAM);entecavir (ETV) |
Literature Information
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PubMed PMID
|
18571815
|
|
Disease
|
Chronic hepatitis B
|
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Published Year
|
2008 |
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Journal
|
Hepatology (Baltimore, Md.) |
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Title
|
Defective hepatitis B virus DNA is not associated with disease status but is reduced by polymerase mutations associated with drug resistance. |
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Author
|
Preiss S,Littlejohn M,Angus P,Thompson A,Desmond P,Lewin SR,Sasadeusz J,Matthews G,Dore GJ,Shaw T,Sozzi V,Yuen L,Lau G,Ayres A,Thio C,Avihingsanon A,Ruxrungtham K,Locarnini S,Revill PA |
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Evidence
|
Reduced intracellular and extracellular % dDNA was observed for the LMV-R mutants (rtM204I, rtL180M + M204V, and rtL180M + T184G + S202I + M204V), ranging from a 20% to 50% reduction.
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HBV Mutation Detail Information