|
Mutation Information
|
Mutation Site
|
L180M |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.M204I+rt.L180M;rt.M204V+rt.L180M |
|
Relevant Drug
|
entecavir (ETV) |
Literature Information
|
PubMed PMID
|
19669299
|
|
Published Year
|
2008 |
|
Journal
|
Hepatology international |
|
Title
|
Primary resistance, multidrug resistance, and cross-resistance pathways in HBV as a consequence of treatment failure. |
|
Author
|
Locarnini S |
|
Evidence
|
In naive patients treated with ETV, atleast three mutations arising at the same time are required: rtL180M + rtM204V plus either one of rtT184, rtS202 or rtM250 codon changes.
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HBV Mutation Detail Information