|
Mutation Information
|
Mutation Site
|
A222T |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Combined Mutation
|
rt.F221Y+rt.A222T |
|
Country
|
India |
Literature Information
|
PubMed PMID
|
25333524
|
|
Disease
|
Hepatocellular carcinoma;
Liver cirrhosis
|
|
Published Year
|
2014 |
|
Journal
|
PloS one |
|
Title
|
Novel point and combo-mutations in the genome of hepatitis B virus-genotype D: characterization and impact on liver disease progression to hepatocellular carcinoma. |
|
Author
|
Datta S,Ghosh A,Dasgupta D,Ghosh A,Roychoudhury S,Roy G,Das S,Das K,Gupta S,Basu K,Basu A,Datta S,Chowdhury A,Banerjee S |
|
Evidence
|
The preS/S ORF is completely overlapped to the polymerase gene. The L213I mutation (TTA to ATG) in surface leads to F221Y and A222T dual mutations in reverse transcriptase (RT) domain of HBV polymerase resulting a change in polymerase activity or viral replication
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|
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HBV Mutation Detail Information