|
Mutation Information
|
Mutation Site
|
N124D |
|
Mutation Type
|
Amino acid level |
|
Gene/Protein/Region Type
|
RT |
|
Genotype/Subtype
|
B |
|
Viral Reference
|
M54923.1
|
|
Relevant Drug
|
lamivudine (LAM) |
|
Country
|
China |
Literature Information
|
PubMed PMID
|
22001270
|
|
Disease
|
HBV infection
|
|
Published Year
|
2012 |
|
Journal
|
The Journal of antimicrobial chemotherapy |
|
Title
|
Identification of hepatitis B virus rtS117F substitution as a compensatory mutation for rtM204I during lamivudine therapy. |
|
Author
|
Lin CL,Chien RN,Hu CC,Lai MW,Yeh CT |
|
Evidence
|
RESULTS: Of the 49 patients carrying the rtM204I mutation, 5 subsequently developed an rtS117F substitution during the follow-up, whereas 4 harboured an rtN124D substitution prior to the development of the rtM204I mutation.
|
|
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HBV Mutation Detail Information